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Article

The spindle positioning protein Kar9p interacts with the sumoylation machinery in Saccharomyces cerevisiae.

Genetics - 1 Dec 2008

Meednu Nida, Hoops Harold, D'Silva Sonia, Pogorzala Leah, Wood Schuyler, Farkas David, Sorrentino Mark, Sia Elaine, Meluh Pam, Miller Rita K

Abstract excerpt

Accurate positioning of the mitotic spindle is important for the genetic material to be distributed evenly in dividing cells, but little is known about the mechanisms that regulate this process. Here we report that two microtubule-associated proteins important for spindle positioning interact with several proteins in the sumoylation pathway. By two-hybrid analysis, Kar9p and Bim1p interact with the yeast SUMO...

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Identifiers

PMID: 18832349
DOI: 10.1534/genetics.108.095042
PMCID: PMC2600940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The spindle positioning protein Kar9p interacts with the sumoylation machinery in Saccharomyces cerevisiae.PMID 18832349Read ↗

The cyclin-dependent kinase Cdc28p regulates multiple aspects of Kar9p function in yeast.Semantic proximity Read ↗

Bim1p/Yeb1p mediates the Kar9p-dependent cortical attachment of cytoplasmic microtubules.Semantic proximity Read ↗

Sumoylation of the budding yeast kinetochore protein Ndc10 is required for Ndc10 spindle localization and regulation of anaphase spindle elongation.Semantic proximity Read ↗

The MEN mediates the effects of the spindle assembly checkpoint on Kar9-dependent spindle pole body inheritance in budding yeast.Semantic proximity Read ↗

The CLIP-170 orthologue Bik1p and positioning the mitotic spindle in yeast.Semantic proximity Read ↗

Microtubule-associated proteins and motors required for ectopic microtubule array formation in Saccharomyces cerevisiae.Semantic proximity Read ↗

The yeast SUMO isopeptidase Smt4/Ulp2 and the polo kinase Cdc5 act in an opposing fashion to regulate sumoylation in mitosis and cohesion at centromeres.Semantic proximity Read ↗

Stu1p is physically associated with beta-tubulin and is required for structural integrity of the mitotic spindle.Semantic proximity Read ↗

The regulation of microtubule dynamics in Saccharomyces cerevisiae by three interacting plus-end tracking proteins.Semantic proximity Read ↗

Kar9 symmetry breaking alone is insufficient to ensure spindle alignment.Semantic proximity Read ↗

SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores.Semantic proximity Read ↗

The CLIP-170 homologue Bik1p promotes the phosphorylation and asymmetric localization of Kar9p.Semantic proximity Read ↗

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