Article
A small C-terminal sequence of Aurora B is responsible for localization and function.
Molecular biology of the cell - 1 Jan 2005
Scrittori Laetitia, Skoufias Dimitrios A, Hans Fabienne, Gerson Véronique, Sassone-Corsi Paolo, Dimitrov Stefan, Margolis Robert L
Abstract excerpt
Aurora B, a protein kinase required in mitosis, localizes to inner centromeres at metaphase and the spindle midzone in anaphase and is required for proper chromosome segregation and cytokinesis. Aurora A, a paralogue of Aurora B, localizes instead to centrosomes and spindle microtubules. Except for distinct N termini, Aurora B and Aurora A have highly similar sequences. We have combined small interfering RNA...
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