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Article

Labile anger during interferon alfa treatment is associated with a polymorphism in tumor necrosis factor alpha.

Clinical neuropharmacology - 1 Jul 2010

Lotrich Francis E, Ferrell Robert E, Rabinovitz Mordechai, Pollock Bruce G

Abstract excerpt

OBJECTIVE: Inflammatory cytokines may influence both labile anger and depression. Both psychiatric conditions can occur during interferon alfa-based treatments. Evidence also indicates a central nervous system role for tumor necrosis factor alpha (TNF-alpha), whose expression may be increased by interferon alfa. A polymorphism in the promoter region of TNF-alpha has been associated with various inflammatory...

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Identifiers

PMID: 20661026
DOI: 10.1097/WNF.0b013e3181de8966
PMCID: PMC2911643

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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