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Article

Lack of association of indoleamine 2,3-dioxygenase polymorphisms with interferon-alpha-related depression in hepatitis C.

Brain, behavior, and immunity - 1 Oct 2011

Galvão-de Almeida Amanda, Quarantini Lucas C, Sampaio Aline S, Lyra André C, Parise Carmen Lívia, Paraná Raymundo, de Oliveira Irismar R, Koenen Karestan C, Miranda-Scippa Angela, Guindalini Camila

Abstract excerpt

BACKGROUND: Major depression is a frequent adverse effect of interferon-alpha (IFN-α) therapy. Although the indoleamine 2,3-dioxygenase (IDO) enzyme seems to be involved in the pathophysiology of IFN-α-induced depression, no pharmacogenetic study has investigated whether variation in the IDO gene modifies vulnerability to this adverse effect. METHODS: A cross-sectional study assessing 277 hepatitis C patients...

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PMID: 21693183
DOI: 10.1016/j.bbi.2011.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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