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Article

Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels.

Biological psychiatry - 15 Mar 2010

Su Kuan-Pin, Huang Shih-Yi, Peng Cheng-Yuan, Lai Hsueh-Chou, Huang Chieh-Liang, Chen Yi-Chih, Aitchison Katherine J, Pariante Carmine M

Abstract excerpt

BACKGROUND: Phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2) are the two key enzymes in the metabolism of polyunsaturated fatty acids, which in turn play an important role in cytokine-induced depression and sickness behavior. METHODS: Patients with chronic hepatitis C viral infection (n = 132) were assessed to examine the effects of seven single nucleotide polymorphisms in COX2 and PLA2 genes on the...

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Identifiers

PMID: 20034614
DOI: 10.1016/j.biopsych.2009.11.005
PMCID: PMC2982743

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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