Article
Rapid Regulation of Depression-Associated Genes in a New Mouse Model Mimicking Interferon-α-Related Depression in Hepatitis C Virus Infection.
Molecular neurobiology - 1 Aug 2015
Hoyo-Becerra Carolina, Liu Zijian, Yao Jinghong, Kaltwasser Britta, Gerken Guido, Hermann Dirk M, Schlaak Joerg F
Abstract excerpt
Major depression is a serious side effect of interferon-α (IFN-α), which is used in the therapy of hepatitis C virus (HCV) infection. Due to the lack of reproducible animal models, the mechanisms underlying IFN-α-related depression are largely unknown. We herein established a mouse model, in which murine IFN-α (250 IU/day) and polyinosinic/polycytidylic acid (poly(I:C); 1 μg/day), a toll-like receptor-3 (TLR3)...
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