Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL28B polymorphism is associated with both side effects and clearance of hepatitis C during interferon-alpha therapy.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Mar 2011

Lotrich Francis E, Loftis Jennifer M, Ferrell Robert E, Rabinovitz Mordechai, Hauser Peter

Abstract excerpt

Interferon-α (IFN-α) treatment for hepatitis C virus (HCV) is complicated by depression and related neurovegetative side effects. Recent genome-wide scans identified IL28B gene polymorphisms that associated with HCV clearance. Whether the IL28B polymorphism is also associated with these adverse effects of IFN-α would affect its clinical usefulness. One hundred thirty-three patients were prospectively examined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Hepatitis C

Share to Interferon-alpha

Share to Interferons

Share to Interleukins

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 21133812
DOI: 10.1089/jir.2010.0074
PMCID: PMC3043990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL28B polymorphism is associated with both side effects and clearance of hepatitis C during interferon-alpha therapy.PMID 21133812Read ↗

Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C.Semantic proximity Read ↗

Many patients with interleukin 28B genotypes associated with response to therapy are ineligible for treatment because of comorbidities.Semantic proximity Read ↗

Impact of interleukin-1β single nucleotide polymorphisms and depressive symptoms in individuals with chronic viral hepatitis.Semantic proximity Read ↗

Utilizing genomic polymorphisms to personalize hepatitis C therapies.Semantic proximity Read ↗

Glucocorticoid Receptors, Brain-Derived Neurotrophic Factor, Serotonin and Dopamine Neurotransmission are Associated with Interferon-Induced Depression.Semantic proximity Read ↗

Risk for depression during interferon-alpha treatment is affected by the serotonin transporter polymorphism.Semantic proximity Read ↗

Interferon-gamma (+874) T/A genotypes and risk of IFN-alpha-induced depression.Semantic proximity Read ↗

Promoter polymorphisms of the interferon-alpha receptor gene and development of Interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findings.Semantic proximity Read ↗

A functional serotonin transporter gene polymorphism and depressive effects associated with interferon-alpha treatment.Semantic proximity Read ↗

Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment.Semantic proximity Read ↗

IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection.Semantic proximity Read ↗

Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.