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Article

Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C.

Molecular psychiatry - 1 Jul 2012

Smith A K, Simon J S, Gustafson E L, Noviello S, Cubells J F, Epstein M P, Devlin D J, Qiu P, Albrecht J K, Brass C A, Sulkowski M S, McHutchinson J G, Miller A H

Abstract excerpt

Interferon (IFN)-α treatment for infectious diseases and cancer is associated with significant depressive symptoms that can limit therapeutic efficacy. Multiple mechanisms have been implicated in IFN-α-induced depression including immune, neuroendocrine and neurotransmitter pathways. To further explore mechanisms of IFN-α-induced depression and establish associated genetic risk factors, single nucleotide...

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Identifiers

PMID: 21691274
DOI: 10.1038/mp.2011.67
PMCID: PMC3179823

Genes

IDO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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