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Article

Quantification of ZAP-70 mRNA by real-time PCR is a prognostic factor in chronic lymphocytic leukemia.

Journal of cancer research and clinical oncology - 1 Jun 2012

Wang Yin-Hua, Zou Zhi-Jian, Liu Ling, Zhang Li-Na, Fang Cheng, Zhu Dan-Xia, Fan Lei, Li Jian-Yong, Xu Wei

Abstract excerpt

BACKGROUND: Chronic lymphocytic leukemia (CLL) is heterogeneous with respect to prognosis and clinical outcome. Mutational status of immunoglobulin heavy chain variable region (IGHV) appears to be a particularly strong prognostic marker, but it is difficult to perform in a routine clinical laboratory. ζ-chain-associated protein kinase 70 kDa (ZAP-70) protein detected by flow cytometry is a strong surrogate marker...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22362302
DOI: 10.1007/s00432-012-1177-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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