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Article

Low frequency of Lynch syndrome among young patients with non-familial colorectal cancer.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Nov 2010

Goel Ajay, Nagasaka Takeshi, Spiegel Jennifer, Meyer Richard, Lichliter Warren E, Boland C Richard

Abstract excerpt

BACKGROUND & AIMS: Colorectal cancer (CRC) is uncommon in individuals <50 years old. Lynch syndrome is caused by germline mutations in DNA mismatch repair (MMR) genes and associated with early-onset CRC, but little is known about the proportion of young patients with apparently sporadic CRC who actually have Lynch syndrome. We examined patterns of microsatellite instability (MSI) and MMR genes among patients <50...

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Topics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20655395
DOI: 10.1016/j.cgh.2010.06.030
PMCID: PMC2964436

Genes

MSH6
PMS2
MLH1
MSH2
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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