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Article

Germline Genetic Features of Young Individuals With Colorectal Cancer.

Gastroenterology - 1 Mar 2018

Stoffel Elena M, Koeppe Erika, Everett Jessica, Ulintz Peter, Kiel Mark, Osborne Jenae, Williams Linford, Hanson Kristen, Gruber Stephen B, Rozek Laura S

Abstract excerpt

BACKGROUND & AIMS: The incidence of colorectal cancer (CRC) in individuals younger than 50 years is increasing. We sought to ascertain the proportion of young CRC cases associated with genetic predisposition. METHODS: We performed a retrospective study of individuals diagnosed with CRC at an age younger than 50 years, evaluated by the clinical genetics service at a single tertiary care cancer center from 1998...

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Source

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Identifiers

PMID: 29146522
DOI: 10.1053/j.gastro.2017.11.004
PMCID: PMC5847426

Genes

BRCA1
CHEK2
MLH1
MSH2
MSH6
MUTYH
PMS2
SMAD4

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Source receipt: pubmed, retrieved 7 Sept 2026.

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