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Article

Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 2015

Jenkins Mark A, Dowty James G, Ait Ouakrim Driss, Mathews John D, Hopper John L, Drouet Youenn, Lasset Christine, Bonadona Valérie, Win Aung Ko

Abstract excerpt

PURPOSE: For carriers of germline mutations in DNA mismatch repair genes, the most relevant statistic for cancer prevention is colorectal cancer (Lynch syndrome) risk, particularly in the short term. METHODS: We conducted a meta-analysis of all independent published Lynch syndrome studies reporting age- and sex-dependent colorectal cancer risks. We estimated 5-year colorectal cancer risk over different age...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Source

Identifiers

PMID: 25534380
DOI: 10.1200/JCO.2014.55.8536

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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