Article
Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancer.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Jun 2011
Limburg Paul J, Harmsen William S, Chen Helen H, Gallinger Steven, Haile Robert W, Baron John A, Casey Graham, Woods Michael O, Thibodeau Stephen N, Lindor Noralane M
Abstract excerpt
BACKGROUND & AIMS: Direct germline analysis could be used to screen high-risk patients for mutations in DNA mismatch repair genes associated with Lynch Syndrome. We examined the prevalence of mutations in MLH1, MSH2, and MSH6 in a population-based sample of patients with young-onset (age <50 years) colorectal cancer (CRC). METHODS: Young-onset CRC cases were randomly selected from 3 Colon Cancer Family Registry...
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