Article
Lynch syndrome-associated colorectal carcinoma: frequent involvement of the left colon and rectum and late-onset presentation supports a universal screening approach.
Human pathology - 1 Nov 2013
Hartman Douglas J, Brand Randall E, Hu Huankai, Bahary Nathan, Dudley Beth, Chiosea Simon I, Nikiforova Marina N, Pai Reetesh K
Abstract excerpt
The optimal strategy for screening patients with colorectal carcinoma for Lynch syndrome (LS) is a subject of continued debate in the literature with some advocating universal screening while others arguing for selective screening. We evaluated 1292 colorectal carcinomas for DNA mismatch repair protein abnormalities and identified 150 (11.6%) tumors demonstrating high-levels of microsatellite instability (MSI-H)....
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