Article
Prevalence and clinicopathologic/molecular characteristics of mismatch repair-deficient colorectal cancer in the under-50-year-old Japanese population.
Surgery today - 1 Sept 2017
Suzuki Okihide, Eguchi Hidetaka, Chika Noriyasu, Sakimoto Takehiko, Ishibashi Keiichiro, Kumamoto Kensuke, Tamaru Jun-Ichi, Tachikawa Tetsuhiko, Akagi Kiwamu, Arai Tomio, Okazaki Yasushi, Ishida Hideyuki
Abstract excerpt
PURPOSE: To clarify the prevalence and clinicopathologic/molecular characteristics of mismatch repair (MMR)-deficient colorectal cancer in the young Japanese population. METHODS: Immunohistochemical analyses for MMR proteins (MLH1, MSH2, MSH6, and PMS2) were performed in formalin-fixed paraffin-embedded sections prepared from the resected CRC specimens of 119 consecutive patients aged <50 years old, who underwent...
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