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Article

Population‐based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test

15 Dec 2008

Abstract excerpt

Approximately 1-2% of colorectal cancers (CRC) arise because of germline mutations in DNA mismatch repair genes, referred to as Lynch syndrome. These tumours show microsatellite instability (MSI) and loss of expression of mismatch repair proteins. Pre-symptomatic identification of mutation carriers has been demonstrated to improve survival; however, there is concern that many are not being identified using...

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Share to Colorectal Cancer Screening and Detection
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PMID: 19072991
DOI: 10.1002/ijc.23863

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