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Article

Inosine 5'-monophosphate dehydrogenase 1 haplotypes and association with mycophenolate mofetil gastrointestinal intolerance in pediatric heart transplant patients.

Pediatric transplantation - 1 Nov 2010

Ohmann Erin L, Burckart Gilbert J, Chen Yan, Pravica Vera, Brooks Maria M, Zeevi Adriana, Webber Steven A

Abstract excerpt

MMF, the most commonly used adjuvant immunosuppressant in pediatric heart transplantation, has frequent GI adverse events. SNPs in inosine 5'-monophosphate dehydrogenase I (IMPDH1) may contribute to MMF GI intolerance. Phased haplotypes may have more utility than individual SNPs in candidate gene association studies for complex traits. This study defined common IMPDH1 haplotypes and investigated whether these...

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Identifiers

PMID: 20649757
DOI: 10.1111/j.1399-3046.2010.01367.x
PMCID: PMC2955782

Genes

IMPDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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