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Article

Interpatient variability in IMPDH activity in MMF-treated renal transplant patients is correlated with IMPDH type II 3757T > C polymorphism.

Pharmacogenetics and genomics - 1 Aug 2009

Sombogaard Ferdi, van Schaik Ron H N, Mathot Ron A, Budde Klemens, van der Werf Marloes, Vulto Arnold G, Weimar Willem, Glander Petra, Essioux Laurent, van Gelder Teun

Abstract excerpt

OBJECTIVES: The active metabolite of mycophenolate mofetil (MMF), mycophenolic acid, inhibits the activity of the target enzyme inosine monophosphate dehydrogenase (IMPDH). The aim of this study was to correlate eight different single nucleotide polymorphisms of the IMPDH type II gene to the acti...

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Identifiers

PMID: 19617864
DOI: 10.1097/FPC.0b013e32832f5f1b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19617864-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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