Article
Polymorphisms in type I and II inosine monophosphate dehydrogenase genes and association with clinical outcome in patients on mycophenolate mofetil.
Pharmacogenetics and genomics - 1 Sept 2010
Gensburger Olivier, Van Schaik Ron H N, Picard Nicolas, Le Meur Yannick, Rousseau Annick, Woillard Jean-Baptiste, Van Gelder Teun, Marquet Pierre
Abstract excerpt
BACKGROUND: Type I and II inosine monophosphate dehydrogenases (IMPDH) are the targets of mycophenolic acid (MPA), a widely used immunosuppressant. The aims of this study were: to check the presence of controversial polymorphisms in the IMPDH II gene; to look for new ones; and to investigate potential associations between the most frequent SNPs in both IMPDH genes and clinical outcome in renal transplant...
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