Lymphocyte counts in kidney allograft recipients are associated with IMPDH2 3757T>C gene polymorphism.

doi:10.1016/j.transproceed.2011.08.037

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Article

Lymphocyte counts in kidney allograft recipients are associated with IMPDH2 3757T>C gene polymorphism.

Transplantation proceedings - 1 Oct 2011

Pazik J, Ołdak M, Podgórska M, Lewandowski Z, Sitarek E, Płoski R, Szmidt J, Chmura A, Durlik M, Malejczyk J

Abstract excerpt

Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme for de novo synthesis of guanine nucleotides, is required for lymphocyte proliferation. Inhibition of IMPDH by mycophenolic acid (MPA) constitutes part of an immunosuppressive therapy in kidney allograft recipients. The 3757T>C polymorphic variant (rs11706052) of the IMPDH2 gene, which encodes 1 of 2 IMPDH isoenzymes, has been associated with...

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PMID: 21996196
DOI: 10.1016/j.transproceed.2011.08.037

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IMPDH2

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