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Article

Inosine monophosphate dehydrogenase polymorphisms and renal allograft outcome.

Transplantation - 15 Sept 2012

Shah Sapna, Harwood Steven M, Döhler Bernd, Opelz Gerhard, Yaqoob Muhammad M

Abstract excerpt

BACKGROUND: Interindividual variation in inosine monophosphate dehydrogenase (IMPDH) enzyme activity and adverse effects caused by mycophenolate mofetil (MMF) inhibition may be genetically determined, and if so, transplant recipients should receive personalized dosing regimens of MMF, which would maximize efficacy and minimize toxicity. Some studies have demonstrated a relationship between the single nucleotide...

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PMID: 22960765
DOI: 10.1097/TP.0b013e31825b7654

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Inosine monophosphate dehydrogenase polymorphisms and renal allograft outcome.PMID 22960765Read ↗

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