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Article

Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics.

British journal of pharmacology - 1 Dec 2010

Wu T-Y, Peng Y, Pelleymounter L L, Moon I, Eckloff B W, Wieben E D, Yee V C, Weinshilboum R M

Abstract excerpt

BACKGROUND AND PURPOSE: Inosine monophosphate dehydrogenases, encoded by IMPDH1 and IMPDH2, are targets for the important immunosuppressive drug, mycophenolic acid (MPA). Variation in MPA response may result, in part, from genetic variation in IMPDH1 and IMPDH2. EXPERIMENTAL APPROACH: We resequen...

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Source

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Identifiers

PMID: 20718729
DOI: 10.1111/j.1476-5381.2010.00987.x
PMCID: PMC3010569

Genes

IMPDH2
IMPDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20718729-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics.PMID 20718729Read ↗

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