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Article

On the use of allelic transmission rates for assessing gene-by-environment interaction in case-parent trios.

Annals of human genetics - 1 Sept 2010

Shin Ji-Hyung, McNeney Brad, Graham Jinko

Abstract excerpt

Allelic transmission rates from parents to cases are frequently stratified by an environmental risk factor E and compared, with heterogeneity interpreted as gene-environment interaction or GxE. Though generally invalid, such analyses continue to appear. We revisit why heterogeneity is not equivalent to GxE in a range of settings not considered previously. The objective is a fuller understanding of the bias in...

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Source

Identifiers

PMID: 20649530
DOI: 10.1111/j.1469-1809.2010.00599.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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