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Article

Does accounting for gene-environment (GxE) interaction increase the power to detect the effect of a gene in a multifactorial disease?

Genetic epidemiology - 1 Apr 2003

Selinger-Leneman Hana, Genin Emmanuelle, Norris Jill M, Khlat Myriam

Abstract excerpt

Despite tremendous efforts, few genes involved in the susceptibility for complex disorders have been identified. One explanation is that these disorders are a result of an interaction between genes and environment, and under such conditions, it may be difficult to measure the true genetic effect without accounting for the interaction. Umbach and Weinberg ([2000] Am. J. Hum. Genet. 66:251-261) proposed an...

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PMID: 12652524
DOI: 10.1002/gepi.10221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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