Article
Estimating the single nucleotide polymorphism genotype misclassification from routine double measurements in a large epidemiologic sample.
American journal of epidemiology - 15 Oct 2008
Heid Iris M, Lamina Claudia, Küchenhoff Helmut, Fischer Guido, Klopp Norman, Kolz Melanie, Grallert Harald, Vollmert Caren, Wagner Stefanie, Huth Cornelia, Müller Julia, Müller Martina, Hunt Steven C, Peters Annette, Paulweber Bernhard, Wichmann H-Erich, Kronenberg Florian, Illig Thomas
Abstract excerpt
Previously, estimation of genotype misclassification of single nucleotide polymorphisms (SNPs) as encountered in epidemiologic practice and involving thousands of subjects was lacking. The authors collected representative data on approximately 14,000 subjects from 8 studies and 646,558 genotypes assessed in 2005 by means of matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Overall...
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