Article
Accuracy of haplotype reconstruction from haplotype-tagging single-nucleotide polymorphisms.
American journal of human genetics - 1 Mar 2005
Forton Julian, Kwiatkowski Dominic, Rockett Kirk, Luoni Gaia, Kimber Martin, Hull Jeremy
Abstract excerpt
Many investigators are now using haplotype-tagging single-nucleotide polymorphism (htSNPs) as a way of screening regions of the genome for association with disease. A common approach is to genotype htSNPs in a study population and to use this information to draw inferences about each individual's haplotypic makeup, including SNPs that were not directly genotyped. To test the validity of this approach, we...
Topics
- Biometry
- Female
- Genetic Markers
- Genomics
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Models, Genetic
- Polymorphism, Single Nucleotide