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Article

Reconstituting the frequency spectrum of ascertained single-nucleotide polymorphism data.

Genetics - 1 Dec 2004

Nielsen Rasmus, Hubisz Melissa J, Clark Andrew G

Abstract excerpt

Most of the available SNP data have eluded valid population genetic analysis because most population genetical methods do not correctly accommodate the special discovery process used to identify SNPs. Most of the available SNP data have allele frequency distributions that are biased by the ascertainment protocol. We here show how this problem can be corrected by obtaining maximum-likelihood estimates of the true...

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Identifiers

PMID: 15371362
DOI: 10.1534/genetics.104.031039
PMCID: PMC1448751

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