Article

Immunometabolic effects of lactate on B cell function in healthy individuals of different ages

2023-08-09

Abstract excerpt

Aging is characterized by chronic systemic inflammation and metabolic changes. When we compared B cells from young and elderly donors, we found that aging induces higher oxygen consumption rates, and especially higher extracellular acidification rates, measures of oxidative phosphorylation and of anaerobic glycolysis, respectively. Importantly, this higher metabolic status, which reflects the age-associated expans...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b474a76-5eb3-5376-82e7-b43539245ca6
DOI: 10.1101/2023.08.07.23293760

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunometabolic effects of lactate on B cell function in healthy individuals of different agesDOI 10.1101/2023.08.07.23293760Read

Understanding the role of host metabolites in the induction of immune senescence: Future strategies for keeping the ageing population healthySemantic proximity Read

Altered basal lipid metabolism underlies the functional impairment of naive CD8 <sup>+</sup> T cells in elderly humansSemantic proximity Read

Does metabolic reprogramming underpin age-associated changes in T cell phenotype and function?Semantic proximity Read

Characterization of the metabolic phenotype of chronically activated lymphocytes.Semantic proximity Read

Metabolic imbalance driving immune cell phenotype switching in autoimmune disorders: Tipping the balance of T- and B-cell interactions.Semantic proximity Read

Metabolic Program of Regulatory B Lymphocytes and Influence in the Control of Malignant and Autoimmune Situations.Semantic proximity Read

Monocytes from Older Adults Maintain Capacity for Metabolic Compensation during Glucose Deprivation and Lipopolysaccharide StimulationSemantic proximity Read

Longevity Humans Have Youthful Erythrocyte Function and Metabolic SignaturesSemantic proximity Read

High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cellsSemantic proximity Read

<scp>H</scp>uman<scp> CD4</scp><sup><scp>+</scp></sup><scp> T </scp>cells maintain specific functions even under conditions of extremely restricted<scp> ATP</scp> productionSemantic proximity Read

Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.Semantic proximity Read

Epigenetic Modulation by Lactylation in Sepsis: Linking Metabolism to Immune DysfunctionSemantic proximity Read