Article
De novo truncating mutation in Kinesin 17 associated with schizophrenia.
Biological psychiatry - 1 Oct 2010
Tarabeux Julien, Champagne Nathalie, Brustein Edna, Hamdan Fadi F, Gauthier Julie, Lapointe Mathieu, Maios Claudia, Piton Amélie, Spiegelman Dan, Henrion Edouard, Millet Bruno, Rapoport Judith L, Delisi Lynn E, Joober Ridha, Fathalli Ferid, Fombonne Eric, Mottron Laurent, Forget-Dubois Nadine, Boivin Michel, Michaud Jacques L, Lafrenière Ronald G, Drapeau Pierre, Krebs Marie-Odile, Rouleau Guy A
Abstract excerpt
BACKGROUND: Schizophrenia (SCZ) is one of the most disabling psychiatric disorders. It is thought to be due to a complex interplay between polygenic and various environmental risk factors, although recent reports on genomic copy number variations suggest that a fraction of the cases could result from variably penetrant de novo variants. The gene encoding the synaptic motor protein kinesin 17 (KIF17) involved in...
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