Article
Identification of rare variants in KCTD13 at the schizophrenia risk locus 16p11.2.
Psychiatric genetics - 1 Dec 2016
Degenhardt Franziska, Heinemann Barbara, Strohmaier Jana, Pfohl Marvin A, Giegling Ina, Hofmann Andrea, Ludwig Kerstin U, Witt Stephanie H, Ludwig Michael, Forstner Andreas J, Albus Margot, Schwab Sibylle G, Borrmann-Hassenbach Margitta, Lennertz Leonard, Wagner Michael, Hoffmann Per, Rujescu Dan, Maier Wolfgang, Cichon Sven, Rietschel Marcella, Nöthen Markus M
Abstract excerpt
Duplications in 16p11.2 are a risk factor for schizophrenia (SCZ). Using genetically modified zebrafish, Golzio and colleagues identified KCTD13 within 16p11.2 as a major driver of the neuropsychiatric phenotype observed in humans. The aims of the present study were to explore the role of KCTD13 in the development of SCZ and to provide a more complete picture of the allelic architecture at this risk locus. The...
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