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Article

Identification and functional characterization of rare SHANK2 variants in schizophrenia.

Molecular psychiatry - 1 Dec 2015

Peykov S, Berkel S, Schoen M, Weiss K, Degenhardt F, Strohmaier J, Weiss B, Proepper C, Schratt G, Nöthen M M, Boeckers T M, Rietschel M, Rappold G A

Abstract excerpt

Recent genetic data on schizophrenia (SCZ) have suggested that proteins of the postsynaptic density of excitatory synapses have a role in its etiology. Mutations in the three SHANK genes encoding for postsynaptic scaffolding proteins have been shown to represent risk factors for autism spectrum disorders and other neurodevelopmental disorders. To address if SHANK2 variants are associated with SCZ, we sequenced...

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Identifiers

PMID: 25560758
DOI: 10.1038/mp.2014.172
PMCID: PMC4653611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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