Article
Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes.
PloS one - 1 Jan 2014
Guipponi Michel, Santoni Federico A, Setola Vincent, Gehrig Corinne, Rotharmel Maud, Cuenca Macarena, Guillin Olivier, Dikeos Dimitris, Georgantopoulos Georgios, Papadimitriou George, Curtis Logos, Méary Alexandre, Schürhoff Franck, Jamain Stéphane, Avramopoulos Dimitri, Leboyer Marion, Rujescu Dan, Pulver Ann, Campion Dominique, Siderovski David P, Antonarakis Stylianos E
Abstract excerpt
Schizophrenia (SCZ) is a severe, debilitating mental illness which has a significant genetic component. The identification of genetic factors related to SCZ has been challenging and these factors remain largely unknown. To evaluate the contribution of de novo variants (DNVs) to SCZ, we sequenced the exomes of 53 individuals with sporadic SCZ and of their non-affected parents. We identified 49 DNVs, 18 of which...
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