Article
De novo mutations from sporadic schizophrenia cases highlight important signaling genes in an independent sample.
Schizophrenia research - 1 Aug 2015
Kranz Thorsten M, Harroch Sheila, Manor Orly, Lichtenberg Pesach, Friedlander Yechiel, Seandel Marco, Harkavy-Friedman Jill, Walsh-Messinger Julie, Dolgalev Igor, Heguy Adriana, Chao Moses V, Malaspina Dolores
Abstract excerpt
Schizophrenia is a debilitating syndrome with high heritability. Genomic studies reveal more than a hundred genetic variants, largely nonspecific and of small effect size, and not accounting for its high heritability. De novo mutations are one mechanism whereby disease related alleles may be introduced into the population, although these have not been leveraged to explore the disease in general samples. This...
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