Article
Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility.
Journal of cell science - 1 Feb 2014
Lang Bing, Pu Jin, Hunter Irene, Liu Min, Martin-Granados Cristina, Reilly Thomas J, Gao Guo-Dong, Guan Zhen-Long, Li Wei-Dong, Shi Yong-Yong, He Guang, He Lin, Stefánsson Hreinn, St Clair David, Blackwood Douglas H, McCaig Colin D, Shen Sanbing
Abstract excerpt
Although many pathogenic copy number variations (CNVs) are associated with neuropsychiatric diseases, few of them have been functionally characterised. Here we report multiple schizophrenia cases with CNV abnormalities specific to unc-51-like kinase 4 (ULK4), a serine/threonine kinase gene. Deletions spanning exons 21-34 of ULK4 were present in 4 out of 3391 schizophrenia patients from the International...
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