Article
Autosomal dominant restless legs syndrome maps to chromosome 20p13 (RLS-5) in a Dutch kindred.
Movement disorders : official journal of the Movement Disorder Society - 15 Aug 2010
Sas Antonetta M G, Di Fonzo Alessio, Bakker Stef L M, Simons Erik J, Oostra Ben A, Maat-Kievit Anneke J, Boon Agnita J W, Bonifati Vincenzo
Abstract excerpt
Six chromosomal loci have been mapped for restless legs syndrome (RLS) through family-based linkage analysis (RLS-1 to RLS-6), but confirmation has met with limited success, and causative mutations have not yet been identified. We ascertained a large multigenerational Dutch family with RLS of early onset (average 18 years-old). The clinical study included a follow-up of 2 years. To map the underlying genetic...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Chromosome Mapping
- Chromosomes, Human, Pair 20
- Female
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Lod Score