Article
Suggestive evidence for linkage for restless legs syndrome on chromosome 19p13.
Neurogenetics - 1 May 2008
Kemlink David, Plazzi Giuseppe, Vetrugno Roberto, Provini Federica, Polo Olli, Stiasny-Kolster Karin, Oertel Wolfgang, Nevsimalova Sona, Sonka Karel, Högl Birgit, Frauscher Birgit, Hadjigeorgiou Georgios M, Pramstaller Peter P, Lichtner Peter, Meitinger Thomas, Müller-Myshok Bertram, Winkelmann Juliane, Montagna Pasquale
Abstract excerpt
Five loci for restless legs syndrome (RLS) on chromosomes 12q, 14q, 9p, 2q, and 20p (RLS1-RLS5) have been mapped in RLS families, with a recessive in the first and autosomal-dominant mode of inheritance in the latter cases. Investigations of further RLS families showed evidence for genetic locus heterogeneity. We have conducted a genome-wide linkage analysis in a large RLS family of Italian origin with 12...
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