Article
Family-based association study of the restless legs syndrome loci 2 and 3 in a European population.
Movement disorders : official journal of the Movement Disorder Society - 15 Jan 2007
Kemlink David, Polo Olli, Montagna Pasquale, Provini Federica, Stiasny-Kolster Karin, Oertel Wolfgang, de Weerd Al, Nevsimalova Sona, Sonka Karel, Högl Birgit, Frauscher Birgit, Poewe Werner, Trenkwalder Claudia, Pramstaller Peter P, Ferini-Strambi Luigi, Zucconi Marco, Konofal Eric, Arnulf Isabelle, Hadjigeorgiou Georgios M, Happe Svenja, Klein Christine, Hiller Anja, Lichtner Peter, Meitinger Thomas, Müller-Myshok Betram, Winkelmann Juliane
Abstract excerpt
Three loci for the restless legs syndrome (RLS) on chromosomes 12q, 14q, and 9p (RLS1, RLS2, and RLS3) have been mapped, but no gene has been identified as yet. RLS1 has been confirmed in families from three different populations. We conducted a family-based association study of 159 European RLS trios. The subjects were genotyped using microsatellite markers evenly covering the candidate regions on chromosomes...
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