Article
Autosomal-dominant locus for Restless Legs Syndrome in French-Canadians on chromosome 16p12.1.
Movement disorders : official journal of the Movement Disorder Society - 15 Jan 2009
Levchenko Anastasia, Montplaisir Jacques-Yves, Asselin Géraldine, Provost Sylvie, Girard Simon L, Xiong Lan, Lemyre Emmanuelle, St-Onge Judith, Thibodeau Pascale, Desautels Alex, Turecki Gustavo, Gaspar Claudia, Dubé Marie-Pierre, Rouleau Guy A
Abstract excerpt
We describe an autosomal-dominant locus for Restless Legs Syndrome (RLS) in a French-Canadian (FC) pedigree. Genome-wide microsatellite scan and linkage analysis were used in this study. The locus maps to chromosome 16p12.1 and spans 1.18 Mega bases. The maximum multipoint LOD scores are of 3.5 over the total of 10 markers. Evidence for the same locus was also found in a smaller FC pedigree sime095. The analysis...
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