Article
Evidence for linkage of restless legs syndrome to chromosome 9p: are there two distinct loci?
Neurology - 26 Feb 2008
Lohmann-Hedrich K, Neumann A, Kleensang A, Lohnau T, Muhle H, Djarmati A, König I R, Pramstaller P P, Schwinger E, Kramer P L, Ziegler A, Stephani U, Klein C
Abstract excerpt
BACKGROUND: Restless legs syndrome (RLS) is a common sensory-motor disorder characterized by paresthesias and an intense urge to move the legs with a considerable familial aggregation. To date, no gene mutation has been found, but five gene loci have been mapped in primary RLS to chromosomes 12q, 14q, 9p, 2q, and 20p (RLS1 through 5). PATIENTS/METHODS: We identified a four-generational German RLS family with 37...
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