Article
The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel.
Neuron - 4 Aug 2005
Lai Helen C, Grabe Michael, Jan Yuh Nung, Jan Lily Yeh
Abstract excerpt
In voltage-gated ion channels, the S4 transmembrane segment responds to changes in membrane potential and controls channel opening. The local environment of S4 is still unknown, even regarding the basic question as to whether S4 is close to the pore domain. Relying on the ability of functional KAT1 channels to rescue potassium (K+) transport-deficient yeast, we have performed an unbiased mutagenesis screen aimed...
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