Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury.

Nature genetics - 1 Aug 2010

Singer Jonathan B, Lewitzky Steve, Leroy Elisabeth, Yang Fan, Zhao Xiaojun, Klickstein Lloyd, Wright Timothy M, Meyer Joanne, Paulding Charles A

Abstract excerpt

Lumiracoxib is a selective cyclooxygenase-2 inhibitor developed for the symptomatic treatment of osteoarthritis and acute pain. Concerns over hepatotoxicity have contributed to the withdrawal or non-approval of lumiracoxib in most major drug markets worldwide. We performed a case-control genome-wide association study on 41 lumiracoxib-treated patients with liver injury (cases) and 176 matched lumiracoxib-treated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclooxygenase 2
Share to Genes, MHC Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Testing

Share to HLA-DQ alpha-Chains

Share to HLA-DQ Antigens

Share to HLA-DQ beta-Chains

Share to HLA-DRB1 Chains

Share to HLA-DRB5 Chains

Source

Identifiers

PMID: 20639878
DOI: 10.1038/ng.632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury.PMID 20639878Read ↗

In silicoanalysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteersSemantic proximity Read ↗

HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury.Semantic proximity Read ↗

Genome-Wide Association Studies for Idiosyncratic Drug-Induced Hepatotoxicity: Looking Back-Looking Forward to Next-Generation Innovation.Semantic proximity Read ↗

Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01.Semantic proximity Read ↗

Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury.Semantic proximity Read ↗

Genome-Wide Association Studies in Drug-Induced Liver Injury: Step Change in Understanding the Pathogenesis.Semantic proximity Read ↗

Genetic variants associated with immune-mediated liver injury from checkpoint inhibitors.Semantic proximity Read ↗

Genome-wide Association Study of Methotrexate-Induced Liver Injury in Rheumatoid Arthritis Patients.Semantic proximity Read ↗

HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.Semantic proximity Read ↗

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.Semantic proximity Read ↗

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.Semantic proximity Read ↗

Newly identified genetic variants associated with idiosyncratic drug-induced liver injury.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.