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Article

Genetic variants associated with immune-mediated liver injury from checkpoint inhibitors.

Hepatology communications - 1 Sept 2024

Fontana Robert J, Li Yi-Ju, Chen Vincent, Kleiner David, Stolz Andrew, Odin Joe, Vuppalanchi Raj, Gu Jiezhun, Dara Lily, Barnhart Huiman

Abstract excerpt

BACKGROUND: The clinical features, liver histology, and genetic variants in 57 patients with moderate to severe immune-mediated liver injury from checkpoint inhibitors (ILICI) are presented. METHODS: Between 2010 and 2022, 57 high-causality ILICI cases were enrolled in the Drug-Induced Liver Injury Network. HLA and selected candidate gene variants were tested for association with ILICI risk compared to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39185906
DOI: 10.1097/HC9.0000000000000518
PMCID: PMC11357698

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