HLA and non-HLA genetic analyses reveal suggestive variants associated with statin-induced liver injury.

doi:10.1097/HC9.0000000000001026

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Article

HLA and non-HLA genetic analyses reveal suggestive variants associated with statin-induced liver injury.

Hepatology communications - 1 Sept 2026

Zaborenko Callie Jo, Schwantes-An Tae-Hwi, Li Yi-Ju, Dellinger Andrew, Nicoletti Paola, Daly Ann K, Aithal Guruprasad, Chalasani Naga

Abstract excerpt

BACKGROUND: Statins are widely prescribed for cardiovascular risk reduction and are generally well tolerated. However, they can cause drug-induced liver injury (DILI), and the genetic factors contributing to statin-DILI remain poorly understood. METHODS: HLA association and genome-wide association (GWAS) studies were conducted to identify genetic variants associated with statin-DILI. High-confidence cases (n=71)...

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Topics

Humans
Chemical and Drug Induced Liver Injury
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Female
Male
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Genetic Predisposition to Disease

Aged

Case-Control Studies

HLA-DQ alpha-Chains

HLA Antigens

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42684112
DOI: 10.1097/HC9.0000000000001026
PMCID: PMC13533501

Genes

FRMD4A
RGS1

Provenance

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