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Article

HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2005

Hung Shuen-Iu, Chung Wen-Hung, Liou Lieh-Bang, Chu Chen-Chung, Lin Marie, Huang Hsien-Ping, Lin Yen-Ling, Lan Joung-Liang, Yang Li-Cheng, Hong Hong-Shang, Chen Ming-Jing, Lai Ping-Chin, Wu Mai-Szu, Chu Chia-Yu, Wang Kuo-Hsien, Chen Chien-Hsiun, Fann Cathy S J, Wu Jer-Yuarn, Chen Yuan-Tsong

Abstract excerpt

Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The adverse events are unpredictable and carry significant morbidity and mortality. To identify genetic markers for allopurinol-SCAR, we carried out a case-control...

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Identifiers

PMID: 15743917
DOI: 10.1073/pnas.0409500102
PMCID: PMC554812

Genes

MICB
MSH5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.PMID 15743917Read ↗

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Impact of HLA-B*58:01 allele and allopurinol-induced cutaneous adverse drug reactions: evidence from 21 pharmacogenetic studies.Semantic proximity Read ↗

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Immunopathogenesis and risk factors for allopurinol severe cutaneous adverse reactions.Semantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing.Semantic proximity Read ↗

HLA-B*58:01 is an Incomplete Predictor of Allopurinol-Induced Severe Cutaneous Adverse ReactionsSemantic proximity Read ↗

Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in KoreansSemantic proximity Read ↗

HLA-B*58:01 allele is associated with augmented risk for both mild and severe cutaneous adverse reactions induced by allopurinol in Han Chinese.Semantic proximity Read ↗

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A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.Semantic proximity Read ↗

Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury.Semantic proximity Read ↗

HLA-B*58:01 and Risk of Allopurinol-Induced Severe Cutaneous Adverse Reactions in the US.Semantic proximity Read ↗

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