Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-DRB116: 01-DQB105: 02 is a novel genetic risk factor for flupirtine-induced liver injury.

Pharmacogenetics and genomics - 1 May 2016

Nicoletti Paola, Werk Anneke N, Sawle Ashley, Shen Yufeng, Urban Thomas J, Coulthard Sally A, Bjornsson Einar S, Cascorbi Ingolf, Floratos Aris, Stammschulte Thomas, Gundert-Remy Ursula, Nelson Matthew R, Aithal Guruprasad P, Daly Ann K

Abstract excerpt

OBJECTIVE: Flupirtine is a nonopioid analgesic with regulatory approval in a number of European countries. Because of the risk of serious liver injury, its use is now limited to short-term pain management. We aimed to identify genetic risk factors for flupirtine-related drug-induced liver injury (DILI) as these are unknown. MATERIALS AND METHODS: Six flupirtine-related DILI patients from Germany were included in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aminopyridines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

Share to Drug-Induced Hepatotoxicity and Protection

Share to Genome-Wide Association Study

Share to HLA-DQ beta-Chains

Share to HLA-DRB1 Chains

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 26959717
DOI: 10.1097/FPC.0000000000000209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury.PMID 26959717Read ↗

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.Semantic proximity Read ↗

Newly identified genetic variants associated with idiosyncratic drug-induced liver injury.Semantic proximity Read ↗

Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury.Semantic proximity Read ↗

In silicoanalysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteersSemantic proximity Read ↗

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury.Semantic proximity Read ↗

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.Semantic proximity Read ↗

Genome-Wide Association Studies in Drug-Induced Liver Injury: Step Change in Understanding the Pathogenesis.Semantic proximity Read ↗

Research Progress of Pharmacogenomics in Drug-Induced Liver InjurySemantic proximity Read ↗

Genome-Wide Association Studies for Idiosyncratic Drug-Induced Hepatotoxicity: Looking Back-Looking Forward to Next-Generation Innovation.Semantic proximity Read ↗

Genetic risk factors in the development of idiosyncratic drug-induced liver injury.Semantic proximity Read ↗

Drug-induced liver injury: a safety review.Semantic proximity Read ↗

Human leukocyte antigen genetic risk factors of drug-induced liver toxicology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.