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Article

Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01.

The pharmacogenomics journal - 1 Apr 2016

Parham L R, Briley L P, Li L, Shen J, Newcombe P J, King K S, Slater A J, Dilthey A, Iqbal Z, McVean G, Cox C J, Nelson M R, Spraggs C F

Abstract excerpt

Lapatinib is associated with a low incidence of serious liver injury. Previous investigations have identified and confirmed the Class II allele HLA-DRB1*07:01 to be strongly associated with lapatinib-induced liver injury; however, the moderate positive predictive value limits its clinical utility. To assess whether additional genetic variants located within the major histocompatibility complex locus or elsewhere...

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Source

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Identifiers

PMID: 25987243
DOI: 10.1038/tpj.2015.40
PMCID: PMC4819766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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