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Genome-wide Association Study of Methotrexate-Induced Liver Injury in Rheumatoid Arthritis Patients.

Clinical pharmacology and therapeutics - 1 Apr 2023

Eektimmerman Frank, Swen Jesse J, den Broeder Alfons A, Hazes Johanna M W, Kurreeman Fina S, Verstappen Suzanne M M, Nair Nisha, Pawlik Andrzej, Nurmohamed Mike T, Dolžan Vita, Böhringer Stefan, Allaart Cornelia F, Guchelaar Henk-Jan

Abstract excerpt

Hepatotoxicity is a serious adverse drug reaction related to methotrexate (MTX). However, the cause of drug-induced liver injury (DILI) is still unclear and unpredictable. Genetic risk factors may predispose for MTX-DILI. Therefore, we conducted a nested case-control genome-wide association study to explore genetic risk factors associated with MTX-DILI. Seven international groups contributed blood samples and...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Chemical and Drug Induced Liver Injury

Share to Chronic Myeloid Leukemia Treatments

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 36708065
DOI: 10.1002/cpt.2858

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