Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.

doi:10.1097/FPC.0b013e3283589a76

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Article

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.

Pharmacogenetics and genomics - 1 Nov 2012

Urban Thomas J, Shen Yufeng, Stolz Andrew, Chalasani Naga, Fontana Robert J, Rochon James, Ge Dongliang, Shianna Kevin V, Daly Ann K, Lucena M Isabel, Nelson Matthew R, Molokhia Mariam, Aithal Guruprasad P, Floratos Aris, Pe'er Itsik, Serrano Jose, Bonkovsky Herbert, Davern Timothy J, Lee William M, Navarro Victor J, Talwalkar Jayant A, Goldstein David B, Watkins Paul B

Abstract excerpt

BACKGROUND AND AIMS: Drug-induced liver injury (DILI) is a serious adverse drug event that is suspected to have a heritable component. We carried out a genome-wide association study of 783 individuals of European ancestry who experienced DILI due to more than 200 implicated drugs. METHODS: DILI patients from the US-based Drug-Induced Liver Injury Network (n=401) and three international registries (n=382) were...

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PMID: 22968431
DOI: 10.1097/FPC.0b013e3283589a76
PMCID: PMC3636716

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