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Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature

2023-08-11

Abstract excerpt

<h4>ABSTRACT</h4> The accumulation of the microtubule-associated tau protein in and around blood vessels contributes to brain microvascular dysfunction through mechanisms that are incompletely understood. Delivery of nutrients to active neurons in the brain relies on capillary inositol 1,4,5-triphosphate receptor (IP 3 R)–mediated calcium (Ca 2+ ) signals to direct blood flow. The initiation and amplification o...

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Literature Corpus work
9c27cc62-a256-514a-8b25-451716729586
DOI
10.1101/2023.08.08.552492
Open publication

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Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculatureDOI 10.1101/2023.08.08.552492
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