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Article

Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation.

The Journal of biological chemistry - 14 Jul 2006

Ding Huiping, Matthews Tori A, Johnson Gail V W

Abstract excerpt

The microtubule-associated protein tau is hyperphosphorylated and forms neurofibrillary tangles in Alzheimer disease. Additionally caspase-cleaved tau is present in Alzheimer disease brains co-localized with fibrillar tau pathologies. To further understand the role of site-specific phosphorylation and caspase cleavage of tau in regulating its function, constructs of full-length tau (T4) or tau truncated at Asp421...

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Source

Identifiers

PMID: 16687396
DOI: 10.1074/jbc.M511697200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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